Experimental Epilepsy Group (Lund i Sweden)
Här hittar du information om Experimental Epilepsy Group. Du kan eventuellt se öppettider, adress, karta, hemsida, telefonnummer och andra kontaktuppgifter. Den här platsen har visats 70 gånger och uppdaterades senast kl. 13:20 den 27 juli år 2021.
Beskrivning
Epilepsy is one of the most devastating neurological diseases affecting about 1% of the population of the western countries. Despite certain progress in antiepileptic drug development in about 30-40% of cases epileptic seizures do not respond to conventional pharmacological treatment therapies. Recently neuropeptides and neurotrophic factors emerged as strong regulators of excitatory and inhibitory synaptic transmission in the CNS thus offering a potent tool to counteract the seizure activity. However, it is not clear what the role of these agents is in mechanisms of epileptogenesis.
We explore the role of neuropeptides and neurotrophic factors in modulation of excitatory and inhibitory synaptic transmission and epileptogensis in the brain. We use rats and trasngenic mice in combination with in vivo epilepsy models (kindling, status epilepsitcus) and in vitro approaches (patch-clamp in brain slices, optogenetics). One of the specific aims of this research line is to use both direct and indirect targeted gene transfer of neuropeptides and neurotrophic factors into the different brain regions to investigate mechanistic aspects of their action on synaptic transmission and epileptogensis. We also explore seizure-suppressant effects of optogenetic approach in vitro and in vivo in animal models of epilepsy.
This research will help in better understanding of the mechanisms for epileptogenesis and might lead to development of new gene therapy-based strategies for epilepsy treatment.
Address
Epilepsy Center Experimental Epilepsy Group Division of Neurology Department of Clinical Sciences Lu
22184 Lund
Sweden
Kontaktuppgifter
Telefon: ####
Karta
Kategorier
Skola
Närliggande platser
Housing Development & Management-Lund University (0 m)Skånska Möten (0 m)
Delicious Food Sweden AB (0 m)
Köttfritt.se (0 m)
Thaibilar (37 m)
Stenkyrka Mejeri (216 m)
Rinnebäcksskolan (220 m)
Value Innovation R&D (250 m)
Mind of Innovation (250 m)
ELIPE Sverigeklinken AB Kävlinge (259 m)
Närliggande orter
Kävlinge (0,8220 km)Furulund (3,0509 km)
Västra Karaby (4,9187 km)
Lilla Harrie (5,2309 km)
Dösjebro (6,8150 km)
Stångby (6,8371 km)
Väggarp (7,2962 km)
Marieholm (7,6304 km)
Örtofta (7,9059 km)
Annelöv (7,9357 km)
Du kan föreslå förbättringar för denna plats, genom att lägga till / uppdatera beskrivning, adress, position, öppettider med mera. Du kan även begära att platsen tas bort från denna webbplats. Vill du föreslå förbättringar för denna plats eller begära radering? eller föreslå en ny plats?